Neuro-urology and Neuroscience Research
Disorders of voiding and storage of urine in the bladder, including overactive bladder, incontinence, and other lower urinary tract symptoms (LUTS), affect millions of people and become even more prevalent with aging. The incomplete understanding of the mechanisms underlying LUT function hampers treatment.
Basic research conducted in our lab aims to elucidate the molecular and cellular basis of voiding dysfunction. We study the functional and anatomical interface between CNS nuclei and the brainstem micturition control centers in healthy and disease models.
Connecting Neuroscience and Urology: lower urinary tract symptoms (LUTS) are likely caused or exacerbated by dysfunction in neural circuits that control bladder function. Despite some progress in the understanding of the cellular and synaptic circuits in the brain and spinal cord that control reflex and voluntary micturition, significant knowledge gaps remain. We aim to identify the etiology and unravel the underlying neural mechanisms of lost bladder control, which often accompanies neurological disorders, and to provide mechanistic insight to inform the development of novel treatments.
Center for Life Science building
Location: Our lab is located in the Center for Life Science, where many of our collaborators from the Departments of Neurology and Medicine at BIDMC are also located.
Beth Israel Deaconess Medical Center
Center for Life Science
3 Blackfan Street, Boston, MA 02115