Verstegen Lab
 

Welcome to the V- Lab!

Our goal is to contribute groundbreaking science toward unraveling the neural control of bladder function. Research in the lab focuses on the central nervous system (CNS; the brain and spinal cord) components of this control. 

We study neural circuits that drive micturition (urination) and explore how urinary continence is maintained. Our ambition is to identify all functional neuron subtypes in the micturition reflex pathway. We also investigate how signals originating from within (i.e., bladder fullness) are sensed, interpreted and become integrated in neuronal circuits before leading to a micturition event.

By defining the neural dynamics and circuit features that integrate sensory information, and through the functional mapping of CNS circuits that regulate bladder behaviors, our studies may lead to new insights into how bladder stretch sensation is encoded in the brain, as well as into the pathology and treatment of lower urinary tract symptoms (LUTS) and related disorders.

 

** For a post-doctoral fellowship opportunity: please send an email with your CV, a description of your research interests and career goals, and contact information for three references. 


 
 
 

 

Neuroscience and Neuro-urology Research

 

Disorders of storage and voiding of urine in the bladder (these include overactive bladder, incontinence and other lower urinary tract symptoms (LUTS)) affect millions of people, and lack of a complete understanding of the mechanisms underlying LUT function hampers treatment. 

Fundamental/ Basic (i.e., not-clinical) research conducted by our labs is aimed at elucidating the molecular and cellular basis for diseases of voiding dysfunction. We study the function and anatomy of  (neurons in) the brain micturition control centers and the neural circuits, in relation to bladder control, both in healthy and in disease models.

Neuro-urology research: lower urinary tract symptoms (LUTS) are likely caused or exacerbated by dysfunction of neural circuits controlling bladder function. Despite some progress in our understanding of the cellular and synaptic circuits that control reflex and voluntary micturition, significant knowledge gaps remain. We aim to identify the etiology and unravel the underlying neural mechanisms of lost bladder-control as this often accompanies neurological disorders, and our ultimate goal is to provide mechanistic insight, for novel treatments to be developed for patients with these dysfunctions.

 

Center for Life Science building

Center for Life Science building

Location: Our lab is located in the Center for Life Science, where many of our collaborators from the Departments of Neurology and Medicine at BIDMC are also located.

Beth Israel Deaconess Medical Center

Center for Life Science

3 Blackfan Circle, Boston, MA 02215